Introduction to the Endocannabinoid System
http://norml.org/library/item/introduction-to-the-endocannabinoid-system
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
http://press.endocrine.org/doi/full/10.1210/er.2005-0009
Cancer Killing Cannabinoids And The Human Endocannabinoid System
How our Endocannabinoid system can prevent cancer
The Endocannabinoid System and Its Relevance for Nutrition
http://www.annualreviews.org/doi/abs/10.1146/annurev.nutr.012809.104701?journalCode=nutr&
Role of Endocannabinoid Signaling in Anxiety and Depression
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808114/
The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer’s disease.
http://www.ncbi.nlm.nih.gov/pubmed/25147120
Clinical endocannabinoid deficiency (CECD) revisited: can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
http://www.ncbi.nlm.nih.gov/pubmed/24977967
History
History of Cannabis in India
http://www.psychologytoday.com/blog/the-teenage-mind/201106/history-cannabis-in-india
History of Cannabis in Ancient China
http://www.psychologytoday.com/blog/the-teenage-mind/201105/history-cannabis-in-ancient-china
Kaneh Bosm: The Hidden Story of Cannabis in the Old Testament
cannabis
- Tree of Life by The Human Revolution – Song about the remarkable Hemp Plant Cannabis sativa – YouTube
- Tree of Life, winner of 2007 Marijuana Music Awards Best Music Video! An educational music video about the many industrial uses and health benefits of the Am…
- https://www.youtube.com/watch?v=-xvmlNJH4fU&NR=1
- The Flower – YouTube
- The Flower contrasts a utopian society that freely farms and consumes a pleasure giving flower with a society where the same flower is illegal and its consum…
- Cannabis Rising; A tale of truth and healing – YouTube
- Silent short piece that unfolded in my head last spring as Douglas Lakota was putting the finishing touches on Cannabis Rising, a painting I commissioned to …
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cancer
- Cannabidiol inhibits cancer cell invasion … [Biochem Pharmacol. 2010] – PubMed – NCBI
- PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
- Cannabidiol inhibits lung cancer cell invasion and m… [FASEB J. 2012] – PubMed – NCBI
- PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
- Tommy Chong reveals cancer diagnosis – YouTube
- Tommy Chong reveals to CNN’s Don Lemon that he is battling prostate cancer and plans to treat it with cannabis.
- Tommy Chong Cancer Update | The Weed Blog
- Tommy Chong’s Cancer Update Is Encouraging
- Marijuana Cuts Lung Cancer Tumor Growth In Half, Study Shows
- The active ingredient in marijuana cuts tumor growth in common lung cancer in half and significantly reduces the ability of the cancer to spread, say researchers at Harvard University who tested the chemical in both lab and mouse studies.
- The Rick Simpson Story – Cannabis Cure for Cancer – YouTube
- The Rick Simpson Story Entitled ‘Run from the cure’ documents a cancer cure method using hemp-oil and the following history of hemp and its neglection within…
- A Cure For Cancer – Max Igan talks with Rick Simpson – Hemp & Cannibis Miracle Cures – YouTube
- Watch Rick Simpson’s documentary for free, or download it free to watch later.. Rick’s site with much more information can be found here.. http://phoenixtear…
- Czech Republic Legalizes Medical Marijuana Use
- PRAGUE — Czech President Vaclav Klaus has signed into law legislation that makes it legal in the Czech Republic to use marijuana for medical treatment. Klaus gave his approval on Friday, after the law had been approved by both houses of Parliament.
- Hemp Oil Dosage Information – Written by Rick Simpson – YouTube
- The endocannabinoid system in our bodies regulate our cancer defense — so it makes sense that cannabis works effectively in this area, and the science backs…
- 9 Ways to Deepen Healing with Cannabis and Consciousness – Waking Times : Waking Times
- 9 Ways to Deepen Healing with Cannabis and Consciousness
- Cannabinoids destroy cancer | Cannabis Culture
- Can Pot Treat Cancer Without The Devastating Effects of Chemotherapy? | Alternet
- Research shows THC and other compounds found only in marijuana don’t just soothe symptoms; they can shrink tumors and slow the spread of cancer.
- 34 Medical Studies Proving Cannabis Cures Cancer – Waking Times : Waking Times
Cannabis II
Note: Cannabis is a Schedule I drug with no “known” medicinal use according to the Federal government !!!
Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury.
http://www.ncbi.nlm.nih.gov/pubmed/25356537
We have previously shown that the prophylactic treatment with cannabidiol (CBD) reduces inflammation in a model of acute lung injury (ALI).
Peripheral cannabinoid receptor, CB2, regulates bone mass
http://www.pnas.org/content/103/3/696.abstract
Here we show that CB2-deficient mice have a markedly accelerated age-related trabecular bone loss and cortical expansion, although cortical thickness remains unaltered.
Cannabinoids inhibit migration of microglial-like cells to the HIV protein Tat.
http://www.ncbi.nlm.nih.gov/pubmed/21735070
Microglia are a population of macrophage-like cells in the central nervous system (CNS) which, upon infection by the human immunodeficiency virus (HIV), secrete a plethora of inflammatory factors, including the virus-specified trans-activating protein Tat.
Marijuana Smoking Does Not Accelerate Progression of Liver Disease in HIV–Hepatitis C Coinfection: A Longitudinal Cohort Analysis
http://cid.oxfordjournals.org/content/early/2013/06/28/cid.cit378.short
At baseline, 53% had smoked marijuana in the past 6 months, consuming a median of 7 joints/week (IQR, 1–21); 40% smoked daily. There was no evidence that marijuana smoking accelerates progression to significant liver fibrosis (APRI ≥ 1.5) or cirrhosis (APRI ≥ 2; hazard ratio [HR]: 1.02 [0.93–1.12] and 0.99 [0.88–1.12], respectively).
Why Marijuana Treats Arthritis, MS, and Diabetes: New Study Implicates mRNA
Distinct microRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Δ9-tetrahydrocannabinol in vivo: regulation of CCAAT/enhancer-binding protein α by microRNA-690.
http://www.ncbi.nlm.nih.gov/pubmed/24202177
Select miRNA such as miR-690 targeting genes involved in myeloid expansion and differentiation likely play crucial roles in this process and therefore in cannabinoid-induced immunosuppression.
Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.
http://www.ncbi.nlm.nih.gov/pubmed/18681481
All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Delta (9)-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance.
Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
http://rheumatology.oxfordjournals.org/content/45/1/50.long
Seventy-five patients were screened and 58 met the eligibility criteria. Thirty-one were randomized to the CBM and 27 to placebo. Mean (s.d.) daily dose achieved in the final treatment week was 5.4 (0.84) actuations for the CBM and 5.3 (1.18) for placebo. In comparison with placebo, the CBM produced statistically significant improvements in pain on movement, pain at rest, quality of sleep, DAS28 and the SF-MPQ pain at present component.
A Link Between Autism and Cannabinoids: Mutations tied to autism in mice lead to deficits in the signaling pathway activated by marijuana.
Two autism-related mutations in a synapse-adhesion protein lead to deficits in prolonged endocannabinoid signaling in mice. It’s a surprising connection that suggests such signaling problems could be implicated in autism spectrum disorders, according to a paper published today (April 11) in Neuron.
Chemicals within cannabis have powerful antioxidant properties, and scientists believe this can protect the brain from damage.
The study outlines how excessive alcohol consumption results in neuro-degeneration as well as behavioral and cognitive impairments that are hypothesized to contribute to the chronic and relapsing nature of alcoholism.
Study: THC-Like Drug Helps Brain Injuries
http://abcnews.go.com/Health/story?id=117202
Mice that sustained brain injuries were discovered to have elevated levels of a compound known as 2-Arachodonoyl glycerol, or 2-AG. Theorizing that this cannabinoid was produced to prevent damage, the researchers administered more of the compound to injured mice and found it protected the brain.
Cannabichromene In Marijuana Helps Brain Grow, Study Shows
http://www.truthonpot.com/2013/08/20/cannabichromene-in-marijuana-helps-brain-grow-study-shows/
Contrary to popular belief, the brain doesn’t stop growing after reaching a certain age. In fact, brain cells are constantly being generated in adults through a process called neurogenesis.
How CANNABIS can treat cancer: Study finds compound in the plant can help shrink aggressive brain tumours
tetrahydrocannabinol (THC) and cannabidiol (CBD) – were tested as part of the research into brain cancer. The benefits of the cannabis plant elements were known before.
Marijuana Users Have Better Cognitive Skills, Study Finds
http://www.leafscience.com/2014/03/14/marijuana-users-better-cognitive-skills-study-finds/
The study, published March 12 in the Journal of Clinical and Experimental Neuropsychology, found that college students who used marijuana scored better on tests of processing speed and verbal fluency
Effect of marijuana use on outcomes in traumatic brain injury.
http://www.ncbi.nlm.nih.gov/pubmed/25264643
A positive THC screen is associated with decreased mortality in adult patients sustaining TBI.
Effects of Smoking Marijuana on Brain Perfusion and Cognition
http://www.nature.com/npp/journal/v26/n6/full/1395868a.html
Smoking marijuana resulted in intoxication, as assessed by a behavioral rating scale, but did not significantly alter mean behavioral performance on the attention task. Heart rate and blood pressure increased dramatically following smoking of marijuana but not placebo cigarettes. However, mean global CBF did not change significantly.
University Of Saskatchewan Research Suggests Marijuana Analogue Stimulates Brain Cell Growth
http://www.sciencedaily.com/releases/2005/10/051016083817.htm
A synthetic substance similar to ones found in marijuana stimulates cell growth in regions of the brain associated with anxiety and depression, pointing the way for new treatments for these diseases, according to University of Saskatchewan medical research published today in The Journal of Clinical Investigation.
The Cannabis Oil Invention Shona Banda Wouldn’t Hold Secret
http://benswann.com/the-cannabis-oil-invention-shona-banda-wouldnt-hold-secret/
(Shona Banda was the one that made me think eating cannabis could heal me … i was dead otherwise)
Cannabis Killed My Terminal Stage IV Lung Cancer
Marijuana habit not linked to lung cancer
When compared with cannabis smokers who also used tobacco, habitual pot smokers had no significant increase in cancer risk.
Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo.
http://www.ncbi.nlm.nih.gov/pubmed/17621270
Delta(9)-Tetrahydrocannabinol (THC) is the primary cannabinoid of marijuana and has been shown to either potentiate or inhibit tumor growth, depending on the type of cancer and its pathogenesis
A Molecular Link Between the Active Component of Marijuana and Alzheimer’s Disease Pathology
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/
Here, we demonstrate that the active component of marijuana, Δ9-tetrahydrocannabinol (THC), competitively inhibits the enzyme acetylcholinesterase (AChE) as well as prevents AChE-induced amyloid β-peptide (Aβ) aggregation, the key pathological marker of Alzheimer’s disease.
Could a loss of ‘natural cannabis’ in the brain be the reason we get Alzheimer’s disease?
A rogue protein called amyloid-beta, suspected of playing a key role in Alzheimer’s, is believed to block endocannabinoids in the brain in the earliest stages of the disease.
The potential therapeutic effects of THC on Alzheimer’s disease.
http://www.ncbi.nlm.nih.gov/pubmed/25024327
These sets of data strongly suggest that THC could be a potential therapeutic treatment option for Alzheimer’s disease through multiple functions and pathways.
Prevention of Alzheimer’s Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation
http://www.jneurosci.org/content/25/8/1904.long
Our results indicate that cannabinoid receptors are important in the pathology of AD and that cannabinoids succeed in preventing the neurodegenerative process occurring in the disease.
A Radically New Understanding of Alzheimer’s Disease Causes and Cures
http://www.greenmedinfo.com/blog/radically-new-understanding-alzheimers-disease-causes-and-cures
Pineal gland calcification is now found in two-thirds of the adult population.
Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial.
http://www.ncbi.nlm.nih.gov/pubmed/25237116
Our findings point to a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities
The Impact of Cannabis Use on Cognitive Functioning in Patients With Schizophrenia: A Meta-analysis of Existing Findings and New Data in a First-Episode Sample
http://schizophreniabulletin.oxfordjournals.org/content/38/2/316.short
In Study I, a meta-analysis of 10 studies comprising 572 patients with established schizophrenia (with and without comorbid cannabis use) was conducted. Patients with a history of cannabis use were found to have superior neuropsychological functioning. This finding was largely driven by studies that included patients with a lifetime history of cannabis use rather than current or recent use. In Study II, we examined the neuropsychological performance of 85 patients with first-episode psychosis (FEP) and 43 healthy nonusing controls. Relative to controls, FEP patients with a history of cannabis use (FEP + CANN; n = 59) displayed only selective neuropsychological impairments while those without a history (FEP − CANN; n = 26) displayed generalized deficits.
Marijuana Compound Treats Schizophrenia with Few Side Effects: Clinical Trial
A compound found in marijuana can treat schizophrenia as effectively as antipsychotic medications, with far fewer side effects, according to a preliminary clinical trial.
Harvard: Marijuana Doesn’t Cause Schizophrenia
http://psychcentral.com/news/2013/12/10/harvard-marijuana-doesnt-cause-schizophrenia/63148.html
“The results of the current study suggest that having an increased familial morbid risk for schizophrenia may be the underlying basis for schizophrenia in cannabis users and not cannabis use by itself,” note the researchers.
Medical Cannabis Helps ALS Patient Outlive her Own Doctors
http://www.examiner.com/article/medical-cannabis-helps-als-patient-outlive-her-own-doctors
In 1986, she was given 3 – 5 years to live according to her neurologist. Nearly 3 decades later, she is still alive and living with ALS.
Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.
http://www.ncbi.nlm.nih.gov/pubmed/24742657
The blood-brain barrier (BBB) is a complex structure that is composed of cellular elements and an extracellular matrix (ECM). HIV-1 Tat promotes transmigration of monocytes across this barrier, a process that includes interaction with ECM proteins.
There is evidence for the use of cannabinoids for symptomatic treatment of multiple sclerosis
http://www.ncbi.nlm.nih.gov/pubmed/25350886
There is evidence that nabiximols oromucosal spray may reduce subjective symptoms of spasticity and that dronabinol is effective against neuropathic pain in patients with MS. The existing treatment system in Denmark is in conformity with the existing data and there is not sufficient evidence to modify it.
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
http://brain.oxfordjournals.org/content/126/10/2191.full
Therefore, in addition to symptom management, cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other diseases.
Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394820/
Smoked cannabis was superior to placebo in symptom and pain reduction in participants with treatment-resistant spasticity.
Study finds marijuana post-trauma benefits
Giving rats synthetic cannabinoids soon after a traumatic event can prevent post-traumatic stress disorder-like symptoms caused by the trauma and by reminders of it.
Money, Not Morals, Drives Marijuana Prohibition Movement
https://www.opensecrets.org/news/2014/08/money-not-morals-drives-marijuana-prohibition-movement/
Legalization of marijuana could take a bite out of a range of other interest groups, many of which already spend big money in Washington.
Willie Nelson Says Pot Saved His Life
http://www.sfweekly.com/shookdown/2012/05/18/willie-nelson-says-pot-saved-his-life
“When I was out in the bars drinking and fighting I was a little bit less of a peacemaker than I would be if I’d had a coupla hits of a joint and gone and laid down somewhere.” – Willie Nelson
Bill Rosendahl, Los Angeles City Council Member: ‘Medical Marijuana Saved My Life’
http://www.huffingtonpost.com/2013/05/23/bill-rosendahl-medical-marijuana_n_3328068.html
L.A. Councilman Bill Rosendahl’s cancer is in remission — and he credits medical marijuana for this. Wednesday, in a blog post on The Huffington Post, he became the first sitting elected official to detail using pot while in office in hopes he’d further the cause.
The endocannabinoid system and its therapeutic exploitation.
http://www.ncbi.nlm.nih.gov/pubmed/15340387
With novel products already being aimed at the pharmaceutical market little more than a decade since the discovery of cannabinoid receptors, the endocannabinoid system seems to hold even more promise for the future development of therapeutic drugs.
